Alvocidib

Dzina la Chemical:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one

SMILES Kodi:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

InChi kodi:

InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21( 19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17 +/m1/s1

InChi Key:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

Mawu ofunika:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Kusungunuka: 

Posungira: 

Kufotokozera:

Alvocidib ndi mankhwala opangidwa ndi N-methylpiperidinyl chlorophenyl flavone. Monga inhibitor ya cyclin-dependent kinase, alvocidib imapangitsa kuti maselo asamamangidwe poletsa phosphorylation ya cyclin-dependent kinases (CDKs) ndi kutsika-regulating cyclin D1 ndi D3 mawu, zomwe zimapangitsa kuti G1 cell cycle kumangidwa ndi apoptosis. Wothandizira uyu ndiyenso mpikisano woletsa ntchito ya adenosine triphosphate. Yang'anani mayesero azachipatala omwe akugwira ntchito kapena mayesero otsekedwa achipatala pogwiritsa ntchito wothandizira uyu.

Cholinga: CDK