Mtengo wa MC180295

Dzina la Chemical:

Rel-(4-amino-2-(((2S)-bicyclo[2.2.1]heptan-2-yl)amino)thiazol-5-yl)(2-nitrophenyl)methanone

SMILES Kodi:

O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O

InChi kodi:

InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8- 9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1

InChi Key:

JRNXAQINDCOHGS-CBINBANVSA-N

Mawu ofunika:

Kusungunuka: 

Posungira: 

Kufotokozera:

MC180295 ndi yosankha kwambiri CDK9 inhibitor (IC50 = 5 nM). (MC180295 ili ndi ntchito zambiri zotsutsana ndi khansa mu vitro ndipo imagwira ntchito mu zitsanzo za khansa ya vivo. Kuwonjezera apo, CDK9 inhibition imalimbikitsa chitetezo cha mthupi α-PD-1 mu vivo, ndikupangitsa kuti ikhale chandamale chabwino kwambiri cha epigenetic therapy ya khansa.

Cholinga: CDK9