Voruciclib

Voruciclib
  • Dzina:Voruciclib
  • Catalog No.:CPD100904
  • Nambala ya CAS:1000023-04-0
  • Kulemera kwa Molecular:469.84
  • Chemical formula:C22H19ClF3NO5
  • Zofufuza zasayansi zokha, osati za odwala.

    Tsatanetsatane wa Zamalonda

    Zolemba Zamalonda

    Paketi Kukula Kupezeka Mtengo (USD)

    Dzina la Chemical:

    2-(2-Chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran -4-mmodzi

    SMILES Kodi:

    O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

    InChi kodi:

    InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21( 19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

    InChi Key:

    MRPGRAKIAJJGMM-OCCSQVGLSA-N

    Mawu ofunika:

    P1446A05, P1446A-05, P1446A 05, Voruciclib

    Kusungunuka: 

    Posungira: 

    Kufotokozera:

    Voruciclib, yomwe imadziwikanso kuti P1446A-05, ndi protein kinase inhibitor yeniyeni ya cyclin-dependent kinase 4 (CDK4) yokhala ndi ntchito yoletsa antiineoplastic. CDK4 inhibitor P1446A-05 makamaka imaletsa kusintha kwa gawo la CDK4-mediated G1-S, kumanga ma cell njinga ndikuletsa kukula kwa maselo a khansa. Serine / threonine kinase CDK4 imapezeka mu zovuta ndi D-mtundu wa G1 cyclins ndipo ndiye kinase woyamba kutsegulidwa pa mitogenic stimulation, kutulutsa maselo kuchokera pa siteji ya quiescent kupita ku G1 / S kukula kwa njinga; Ma CDK-cyclin complexes awonetsedwa kuti ali ndi phosphorylate the retinoblastoma (Rb) transcript factor kumayambiriro kwa G1, kuchotsa histone deacetylase (HDAC) ndikuletsa kuponderezedwa kwa transcriptional.

    Cholinga: CDK4


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