THZ2
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 500 |
| 500 mg | Zilipo | 800 |
| 1g | Zilipo | 1200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
N--[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)koma-2- enoyl]amino]benzamide
SMILES Kodi:
O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN (C)C)=O)=C5
InChi kodi:
InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26 (32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H, 35,40)(H,36,41)(H,34,37,38)/b14-7+
InChi Key:
FONRCZUZCHXWBD-VGOFMYFVSA-N
Mawu ofunika:
THZ-2, THZ 2, THZ2, 1604810-84-5
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
THZ2, analogi ya THZ1, yokhoza kuchiza khansa ya m'mawere ya Triple-negative (TNBC), ndi CDK7 inhibitor yamphamvu komanso yosankha yomwe imagonjetsa kusakhazikika kwa THZ1 mu vivo. IC50: CDK7= 13.9 nM; Maselo a TNBC = 10 nM
Cholinga: CDK
