Rivicclib

Dzina la Chemical:

2-(2-chlorophenyl) -5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

SMILES Kodi:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

InChi kodi:

InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

InChi Key:

OOVTUOCTLAERQD-OJMBIDBESA-N

Mawu ofunika:

P276-00; P-276-00; P 276-00; P-27600; PA 27600; PA 27600; Riviciclib, Riviciclib HCl

Kusungunuka: 

Posungira: 

Kufotokozera:

Riviciclib, yemwe amadziwikanso kuti P276-00, ndi flavone ndi cyclin dependent kinase (CDK) inhibitor yomwe ingathe kuchitapo kanthu. P276-00 imamangiriza ndikuletsa Cdk4 / cyclin D1, Cdk1 / cyclin B ndi Cdk9 / cyclin T1, serine / threonine kinases yomwe imagwira ntchito yofunika kwambiri pakuwongolera ma cell ndi kuchuluka kwa ma cell. Kuletsa kwa kinasewa kumabweretsa kumangidwa kwa ma cell panthawi ya kusintha kwa G1/S, zomwe zimapangitsa kuti apoptosis alowe, ndikuletsa kuchulukana kwa maselo otupa.

Cholinga: CDK