MEK

MPAKA #	Dzina lazogulitsa	Kufotokozera
Chithunzi cha CPDB0157	BI-847325	BI-847325 ndi yosankha yapawiri ya MEK/Aurora kinase inhibitor yokhala ndi IC50 milingo ya 3, 25, 15, 25, ndi 4 nM ya X. laevis Aurora B, Aurora A yamunthu ndi Aurora C, ndi MEK1 yamunthu ndi MEK2 motsatana. Itha kulepheretsa kukula ndi kupulumuka kwa mizere ya melanoma yopanda chithandizo komanso yosamva mankhwala, kumachepetsa mawu a MEK ndi Mcl-1 ndikuwonjezera kufotokoza kwa pro-apoptotic protein Bim. Pa 70 mg/kg, BI-847325 imapangitsa apoptosis mu mankhwala osachiritsika komanso osamva mankhwala a xenografted melanoma mu vivo.