| Mtengo wa CPDB0099 | Quizartinib; AC-010220; AC-220 | Quizartinib ndi inhibitor ya tyrosine kinase 3 yokhudzana ndi FMS (FLT3; Kd = 1.6 nM) ndipo imasonyeza kusankhidwa kwakukulu kwa FLT3 poyesedwa ndi gulu la 227 kinases. Imalepheretsa kuchuluka kwa maselo a khansa ya m'magazi a anthu a MV4-11, omwe amakhala ndi kusintha kwa homozygous FLT3-ITD, ndi IC50 mtengo wa 0.56 nM.1 Pa 1 mg/kg/tsiku, quizartinib yasonyezedwa kuti ikulitsa moyo mu mbewa. chitsanzo cha FLT3-ITD acute myeloid leukemia ndi kuthetsa zotupa mu chitsanzo cha FLT3 chodalira mbewa xenograft pa 10 mg/kg. |
