LDC000067

Dzina la Chemical:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

SMILES Kodi:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

InChi kodi:

InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6 -4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

InChi Key:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Mawu ofunika:

LDC000067; LDC-000067; Chithunzi cha LDC 000067

Kusungunuka: 

Posungira: 

Kufotokozera:

LDC000067 ndi choletsa champhamvu komanso chosankha cha CDK9. LDC000067 inhibited in vitro transcript mu ATP-mpikisano komanso kutengera mlingo. Kufotokozera kwa ma gene kuma cell omwe amathandizidwa ndi LDC000067 kunawonetsa kuchepetsedwa kosankha kwa ma mRNA osakhalitsa, kuphatikiza owongolera ofunikira pakuchulukira ndi apoptosis. Kuwunika kwa kaphatikizidwe ka de novo RNA kunawonetsa mbali zambiri zabwino za CDK9. Pama cell ndi ma cell, LDC000067 idatulutsanso zotsatira za CDK9 zoletsa monga kuyimitsidwa kwa RNA polymerase II pamajini ndipo, chofunikira kwambiri, kulowetsedwa kwa apoptosis m'maselo a khansa. LDC000067 imalepheretsa kulembedwa kwa P-TEFb mu vitro. Imapangitsa apoptosis mu vitro ndi mu vivo kuphatikiza BI 894999.

Cholinga: CDK9