CP-456773 sodium
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 500 |
| 500 mg | Zilipo | 800 |
| 1g | Zilipo | 1200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)(4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide
SMILES Kodi:
O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
InChi kodi:
InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3- 5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q; +1/p-1
InChi Key:
LFQQNXFKPNZRFT-UHFFFAOYSA-M
Mawu ofunika:
MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 mchere wa sodium, Cytokine kumasulidwa inhibitory mankhwala 3, 256373-9
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
CP-456773, yomwe imadziwikanso kuti MCC950 ndi CRID3, ndi yamphamvu komanso yosankha cytokine release inhibitor ndi NLRP3 inflammasome inhibitor pofuna kuchiza matenda opweteka. CP-456773 imaletsa interleukin 1β (IL-1β) secretion ndi caspase 1 processing. MCC950 yatsekereza canonical and noncanonical NLRP3 activation pa nanomolar concentrations. MCC950 inaletsa mwachindunji kuyambitsa kwa NLRP3 koma osati AIM2, NLRC4 kapena NLRP1 inflammasomes. MCC950 inachepetsa kupanga interleukin-1β (IL-1β) mu vivo ndipo inachepetsa kuopsa kwa kuyesa kwa autoimmune encephalomyelitis (EAE), chitsanzo cha matenda a multiple sclerosis. MCC950 ndi mankhwala omwe angathe kuchiza matenda okhudzana ndi NLRP3, kuphatikizapo matenda a autoimmune ndi autoimmune, komanso chida chophunzirira mopitilira NLRP3 inflammasome mu thanzi la munthu ndi matenda.
Cholinga: NLRP3
