Chithunzi cha BS-181
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
Dzina la Chemical:
N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine hydrochloride
SMILES Kodi:
CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl
InChi kodi:
InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19) 28 )24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2, 1-2H3,(H,24,27);1H
InChi Key:
NVIJWMOQODWNFN-UHFFFAOYSA-N
Mawu ofunika:
Kusungunuka:
Posungira:
Kufotokozera:
BS-181 ndi choletsa kwambiri cha CDK cha CDK7 chokhala ndi IC(50) ya 21 nmol/L. Kuyesedwa kwa ma CDK ena komanso ma kinase ena 69 kunawonetsa kuti BS-181 idangoletsa CDK2 pamalo otsika kuposa 1 micromol/L, pomwe CDK2 idaletsedwa 35-fold less potently (IC(50) 880 nmol/L) kuposa CDK7. M'maselo a MCF-7, BS-181 inaletsa phosphorylation ya magawo a CDK7, kulimbikitsa kumangidwa kwa ma cell cycle ndi apoptosis kuti alepheretse kukula kwa maselo a khansa, ndikuwonetsa zotsatira za antitumor mu vivo.
Cholinga: CDK7
