THZ531

Ingoa matū:

(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (dimethylamino)engari-2-enamide

Waehere SMILES:

"O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C "

Waehere InChi:

InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4, 6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/ t22-/m1/s1

Kī InChi:

RUBYHLPRZRMTJO-MOVYNIQHSA-N

Kupumatua:

THZ-531, THZ 531, THZ531, 1702809-17-3

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te THZ531 ko te CDK12 me te CDK13 te aukati covalent. Ko nga kinases 12 me te 13 (CDK12 me te CDK13) e whakawhirinaki ana ki te Cyclin e whai waahi nui ana i roto i te whakaritenga o te tuhi ira. Ko te THZ531 e aro tonu ana ki tetahi cysteine ​​kei waho o te rohe kinase. Ko te THZ531 ka ngaro te whakaaturanga ira me te ngaronga o te roanga me te hyperphosphorylated RNA polymerase II. Ko te THZ531 he tino whakaheke i te whakapuakitanga o nga ira whakautu kino DNA me nga ira tauwehe whakawhiti-whakanui-nui. Ko te THZ531 i tino whakaawehia te mate o te pūtau apoptotic. Ko nga ngota ngota iti e kaha ki te aro motuhake ki te CDK12 me te CDK13 ka awhina pea ki te tautuhi i nga momo mate pukupuku e tino whakawhirinaki ana ki a raatau mahi kinase.

Whāinga: CDK