Riviciclib

Ingoa matū:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

Waehere SMILES:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

Waehere InChi:

InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

Kī InChi:

OOVTUOCTLAERQD-OJMBIDBESA-N

Kupumatua:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko Riviciclib, e mohiotia ana ko P276-00, he flavone me te cyclin dependent kinase (CDK) aukati me te mahi antineoplastic pea. Ko te P276-00 ka herea, ka aukati i te Cdk4/cyclin D1, Cdk1/cyclin B me Cdk9/cyclin T1, serine/threonine kinases e whai waahi nui ana ki te whakahaere i te huringa o te pūtau me te whakatipu pūtau. Ko te whakakore i enei kinases ka arahi ki te hopu i te huringa pūtau i te wa o te whakawhitinga G1 / S, na reira ka arahina ki te whakauru o te apoptosis, me te aukati i te tipu o te pukupuku pukupuku.

Whāinga: CDK