THZ2

Ingoa matū:

N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)engari-2- enoyl]amino]benzamide

Waehere SMILES:

O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN (C)C)=O)=C5

Waehere InChi:

InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3- 14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+

Kī InChi:

FONRCZUZCHXWBD-VGOFMYFVSA-N

Kupumatua:

THZ-2, THZ 2, THZ2, 1604810-84-5

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te THZ2, he tairitenga o THZ1, me te kaha ki te rongoa i te mate pukupuku o te u Toru-kino (TNBC), he aukati CDK7 kaha me te kowhiria e hinga ai te koretake o te THZ1 in vivo. IC50: CDK7= 13.9 nM; Ngā pūtau TNBC= 10 nM

Whāinga: CDK