Voruciclib

Ingoa matū:

2-(2-Chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran -4-kotahi

Waehere SMILES:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Waehere InChi:

InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(32-21) 1 9)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

Kī InChi:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

Kupumatua:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko Voruciclib, e mohiotia ana ko P1446A-05, he aukati kinase pūmua mo te kinase 4 (CDK4) e whakawhirinaki ana ki te cyclin me te mahi antineoplastic pea. Ko te aukati CDK4 P1446A-05 ka aukati i te whakawhitinga o te wahanga G1-S e CDK4-takawaenga, te hopu i te eke pahikara me te aukati i te tipu o te mate pukupuku. Ko te serine/threonine kinase CDK4 ka kitea i roto i te matatini me nga momo D-momo paihikara G1, a ko te kinase tuatahi ki te whakahohe i runga i te whakaihiihi mitogenic, te tuku i nga pūtau mai i te ata noho ki roto i te wahanga paihikara tipu G1/S; Kua whakaatuhia nga matatini CDK-cyclin ki te phosphorylate te retinoblastoma (Rb) tauwehe whakamaoritanga i te timatanga o te G1, te whakakore i te histone deacetylase (HDAC) me te aukati i te aukati tuhinga.

Whāinga: CDK4