MC180295
Taipitopito Hua
Tohu Hua
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Ingoa matū:
Rel-(4-amino-2-(((2S)-bicyclo[2.2.1]heptan-2-yl)amino)thiazol-5-yl)(2-nitrophenyl)methanone
Waehere SMILES:
O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O
Waehere InChi:
InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16 )19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10? ,12-/m0/s1
Kī InChi:
JRNXAQINDCOHGS-CBINBANVSA-N
Kupumatua:
Wairewa:
Rokiroki:
Whakaahuatanga:
Ko te MC180295 he kaitautoko CDK9 tino whiriwhiri (IC50 = 5 nM). (MC180295 he mahi aukati-mate pukupuku i roto i te vitro me te whai hua i roto i nga tauira mate pukupuku in vivo. Hei taapiri, ko te aukati CDK9 e whakamohio ana ki te aukati α-PD-1 i roto i te vivo, ka waiho hei kaupapa pai mo te rongoa epigenetic o te mate pukupuku.
Whāinga: CDK9
