Alvocidib

Ingoa matū:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one

Waehere SMILES:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

Waehere InChi:

InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(28-21) 19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17 +/m1/s1

Kī InChi:

BIIVYFLTOXDAOV-PXAZEXFGSA-N

Kupumatua:

L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko Alvocidib he pūhui N-methylpiperidinyl chlorophenyl flavone. Hei aukati i te kinase cyclin-dependent, ka whakaawehia e alvocidib te hopu huringa pūtau ma te aukati i te phosphorylation o nga kinases cyclin-dependent (CDKs) me te whakaheke i te cyclin D1 me te D3, ka hua te hopukina huringa pūtau G1 me te apoptosis. Ko tenei kaihoko he kaiwhakataetae whakataetae mo te mahi adenosine triphosphate. Tirohia mo nga whakamatautau haumanu kaha, nga whakamatautau haumanu kati ranei ma te whakamahi i tenei kaihoko.

Whāinga: CDK