MSC2530818

Ingoa matū:

[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

Waehere SMILES:

O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3

Waehere InChi:

InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0/s1

Kī InChi:

ODRITQGYYWHQGM-INIZCTEOSA-N

Kupumatua:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te MSC2530818 he Kaipupuri CDK8 Putea, Whiriwhiria, me te Oraly Bioavailable CDK8 me te CDK8 IC50 = 2.6 nM; Matapae PK tangata: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. Ko te MSC2530818 e whakaatu ana i te whiriwhiringa kinase tino pai, te matū koiora me te kaha o te pūtau, te pumau o te microsomal, me te waatea-a-waha. Ko te MSC2530818 e whakaatu ana i te kaha me te kowhiringa ki te ahu whakamua ki roto i nga rangahau whaihuatanga i roto i te vivo me te haumaru.

Whāinga: CDK