Revefenacin

Aha kemịkalụ:

1- (2- (3- ((4-carbamoylpiperidin-1-yl)methyl) -N-methylbenzamido) ethyl) piperidin-4-yl [1,1'-biphenyl] -2-ylcarbamate

Koodu Ọchịchọ:

O=C(OC1CCN(CCN(C)C(C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2=O)CC1)NC4=CC=CC=C4C5=CC=CC= C5

Koodu InChi:

InChi=1S/C35H43N5O4/c1-38(34(42)29-13-11-26(12-14-29)25-40-19-15-28(16-20-40)33(36)41) 23-24-39-21-17- 30 (18-22-39)44-35(43)37-32-10-6-5-9-31 (32)27-7-3-2-4-8-27/h2-14,28, 30H,15-25H2,1H3,(H2,36,41)(H,37,43)

Igodo InChi:

FYDWDCIFZSGNBU-UHFFFAOYSA-N

Okwu:

Revefenacin, TD-4208, GSK-1160724, TD4208, TD 4208, GSK1160724, GSK 1160724, 864750-70-9

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

Na Vitro: Kis nke revefenacin bụ 0.42, 0.32, 0.18, 0.56, na 6.7 nM na ndị na-anabata M1, M2, M3, M4 na M5, n'otu n'otu. N'ime nyocha ọrụ, a na-egosi revefenacin ka ọ bụrụ onye na-emegide ọrụ nke nwere ihe mgbochi na-adịgide adịgide dị ka njide Ki's. Revefenacin na-egbochikwa mkpụkọ agonist na-akpata nke guinea pig dịpụrụ adịpụ tracheal mgbanaka yana njikọ nke 0.1 nM, nke yiri M3 biding Ki[1]. Na Vivo: N'ime nkịta aneshetized, revefenacin, yana tiotropium na glycopyrronium, na-emepụta mgbochi na-adịgide adịgide nke bronchoconstriction na-akpata acetylcholine ruo awa 24. N'ime oke aneshetized, revefenacin ikuru ume na-egosiputa bronchoprotection nke awa iri abụọ na anọ na-adabere na dose megide bronchoconstriction nke methacholine kpatara. A na-eme atụmatụ ike nke awa 24 bụ 45.0 μg/mL yana a na-edobe ike bronchoprotective mgbe ụbọchị 7 gachara otu ugboro kwa ụbọchị[2].

Ebumnuche: mAChR