CB-839

Aha kemịkalụ:

2- (pyridin-2-yl) -N- (5- (4-- (6---2-- (3- (trifluoromethoxy) phenyl) acetamido) pyridazin-3-yl) butyl) -1,3,4-thiadiazol -2-yl) acetamide

Koodu Ọchịchọ:

O=C(NC1=CC=C(CCCC2=NN=C(NC(CC3=NC=CC=C3)=O)S2)N=N1)CC4=CC(OC(F)(F)F)=CC =C4

Koodu InChi:

InChi=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34- 21)7-1-2-10-24- 35-36-25 (40-24) 32-23 (38) 16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7, 10,15-16H2,(H,31,34,37)(H,32,36,38)

Igodo InChi:

PRAAPINBUWJLGA-UHFFFAOYSA-N

Okwu:

CB-839, CB839, CB 839, 1439399-58-2

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

"CB-839 bụ onye na-emechi ọnụ nke glutaminase, nke nwere ike ịrụ ọrụ antineoplastic. N'elu nchịkwa ọnụ, CB-839 na-ahọrọ na nke na-adịghị agbanwe agbanwe na-egbochi glutaminase, enzyme mitochondrial nke dị mkpa maka ntụgharị nke amino acid glutamine n'ime glutamate. Site na igbochi glutamine. itinye n'ọrụ, mmụba na mkpụrụ ndụ na-eto ngwa ngwa na-emebi emebi. Ụbụrụ na-adabere na glutamine na-adabere na ntụgharị nke glutamine exogenous ka ọ bụrụ glutamate na glutamate metabolites na-enye ike ma na-emepụta ihe mgbochi maka mmepụta nke macromolecules, nke dị mkpa maka uto cellular na nlanarị.

Ebumnuche: Glutaminase