Quizartinib; AC-010220; AC-220

Aha kemịkalụ:

N- (5-tert-Butylisoxazol-3-yl)-N'-{4-[7- (2-morpholin-4-ylethoxy) imidazo[2,1-b] [1,3] benzothiazol-2-yl phenyl}urea

Koodu Ọchịchọ:

O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6

Koodu InChi:

InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

Igodo InChi:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

Okwu:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

Quizartinib bụ onye na-egbochi FMS metụtara tyrosine kinase 3 (FLT3; Kd = 1.6 nM) ma gosipụta oke nhọrọ maka FLT3 mgbe a nwalere ya na panel nke 227 ọzọ kinases. Ọ na-egbochi mmụba nke eriri mkpụrụ ndụ leukemia mmadụ MV4-11, nke na-ebunye ngbanwe nke homozygous FLT3-ITD, yana uru IC50 nke 0.56 nM.1 Na 1 mg / kg / ụbọchị, quizartinib egosila ịgbatị ndụ n'ime òké. ụdị nke FLT3-ITD nnukwu ọrịa leukemia myeloid na ikpochapụ etuto dị na ụdị xenograft òké FLT3 dabere na 10 mg/kg.

Aha njirimara: FLT3