CP-456773 sodium

Aha kemịkalụ:

sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl) ((4- (2-hydroxypropan-2-yl)furan-2-yl) sulfonyl) amide

Koodu Ọchịchọ:

O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]

Koodu InChi:

InChi=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3- 5-12 (15) 9-13-6-4-8-16 (13)18;/h9-11,24H,3-8H2,1-2H3, (H2,21,22,23);/q; +1/p-1

Igodo InChi:

LFQQNXFKPNZRFT-UHFFFAOYSA-M

Okwu:

MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 sodium nnu, Cytokine ntọhapụ ọgwụ mgbochi 3, 256-373-96

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

CP-456773, nke a makwaara dị ka MCC950 na CRID3, bụ onye na-eme ihe ike na-ahọrọ cytokine release inhibitor na NLRP3 inflammasome inhibitor maka ọgwụgwọ ọrịa ndị na-egbuke egbuke. CP-456773 na-egbochi nzuzo interleukin 1β (IL-1β) na nhazi caspase 1. MCC950 gbochiri canonical na noncanonical NLRP3 ịgbalite na mkpokọta nanomolar. MCC950 kpachibidoro ịgbalite NLRP3 mana ọ bụghị mkparị AIM2, NLRC4 ma ọ bụ NLRP1. MCC950 belatara mmepụta interleukin-1β (IL-1β) na vivo wee belata ịdị njọ nke nnwale autoimmune encephalomyelitis (EAE), ụdị ọrịa nke otutu sclerosis. MCC950 bụ ihe nwere ike ịgwọ ọrịa maka ọrịa NLRP3 metụtara ọrịa, gụnyere autoinflammatory na ọrịa autoimmune, yana ngwá ọrụ maka nyocha ọzọ nke NLRP3 inflammasome na ahụike mmadụ na ọrịa.

Ebumnuche: NLRP3