MEK

nwamba #	Aha ngwaahịa	Nkọwa
CPDB0157	BI-847325	BI-847325 bụ nhọrọ abụọ MEK / Aurora kinase inhibitor nwere ụkpụrụ IC50 nke 3, 25, 15, 25, na 4 nM maka X. laevis Aurora B, mmadụ Aurora A na Aurora C, na mmadụ MEK1 na MEK2, n'otu n'otu. Ọ nwere ike igbochi uto na nlanarị nke ahịrị mkpụrụ ndụ melanoma na-adịghị ahụkebe na ọgwụ na-eguzogide ọgwụ, na-ebelata okwu MEK na Mcl-1 ebe ọ na-abawanye okwu pro-apoptotic protein Bim. Na 70 mg / kg, BI-847325 na-ebute apoptosis na ọgwụgwọ-naive na ọgwụ na-eguzogide xenografted melanoma na vivo.