AMG-510

Aha kemịkalụ:

4- ((S) -4-acryloyl-2-methylpiperazin-1-yl) -6-fluoro-7- (2-fluoro-6-hydroxyphenyl) -1- (2-isopropyl-4-methylpyridin-3-yl) )pyrido[2,3-d]pyrimidin-2(1H) -otu

Koodu Ọchịchọ:

O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4=O)CC1

Koodu InChi:

InChi=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22 (24) 39) 34-29 (19) 38 (30 (41) 35-28) 27-17 (4) 10-11-33-25 (27) 16 (2) 3 / h6- 11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

Igodo InChi:

NXQKSXLFSAEQCZ-SFHVURJKSA-N

Okwu:

AMG-510; AMG 510; AMG510

Solubility: 

Nchekwa: 

Nkọwa:

AMG-510 bụ ihe mgbochi covalent KRAS G12C. AMG-510 na-ahọrọ nke ọma na-elekwasị anya na KRAS p.G12C mutant, na DNA, RNA ma ọ bụ protein, ma na-egbochi, site na nke a na-akọwabeghị ya, nkwupụta nke na/ma ọ bụ tumor cell na-egosi site na KRAS p.G12C mutant. Nke a nwere ike igbochi uto na KRAS p.G12C na-egosipụta mkpụrụ ndụ etuto

Ebumnuche: KRAS