ARS-1620

Aha kemịkalụ:

(S) -1- (4- (6-chloro-8-fluoro-7- (2-fluoro-6-hydroxyphenyl)quinazolin-4-yl) piperazin-1-yl) prop-2-en-1-otu

Koodu Ọchịchọ:

C=CC(=O)N1CCN(CC1)C2=C3C=C(C(=C4C(=O)C=CC=C4F)C(=C3NC=N2)F)Cl

Koodu InChi:

InChi=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17(19(24)20(12)25- 11-26-21) 18-14 (23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2

Igodo InChi:

QIQWMIZVWVSRAS-UHFFFAOYSA-N

Okwu:

ARS-1620, KRAS G12C, NSCLC, ARS1620, ARS 1620, KRASG12C, 1698055-85-4

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

ARS-1620 bụ ọgwụ emebere site na ARS-853, nke bụ ihe mgbochi S-IIP G12C nwere ike na nhọrọ. ARS-1620 na-atụ anya na ọ ga-abụ usoro ọgwụgwọ maka p.G12C KRAS mutant cancers.

Ebumnuche: KRAS (K-Ras G12C)