| nwamba # | Aha ngwaahịa | Nkọwa |
| CPD9470 | Obeticolic acid | Obeticholic acid (INT747; 6-ECDCA) bụ akwụkwọ akụkọ ewepụtara nke cholic acid nke na-arụ ọrụ dị ka FXR agonist nwere ike ma họrọ nke na-egosipụta ọrụ anticholeretic na ụdị vivo oke nke cholestasis. Ọ na-egbochi vaskụla ire ụtọ mkpụrụ ndụ mbufụt na mbugharị yana na-akwalite ọdịiche adipocyte ma na-achịkwa ọrụ adipose cell na vivo. |
| CPD100579 | fexaramine | Fexaramine bụ agonist nke farnesoid X receptor (FXR), nke bụ bile acid na-arụ ọrụ nuklia nke na-achịkwa njikọ bile-acid, njikọ na njem, yana metabolism lipid site na imeju na eriri afọ. Fexaramine nwere 100-fold ukwuu mmekọrịta maka FXR karịa eke ogige ma kọwaa genomic lekwasịrị anya na njikọ saịtị na FXR. Mgbe a na-enye ụmụ oke ọnụ ọnụ, fexaramine mepụtara omume nhọrọ site na ndị na-anabata FXR na eriri afọ. |
| CPD100577 | Lithocholic acid | Levallorphan, makwaara dị ka levallorphan tartate (USAN), bụ onye modulator opioid nke ezinụlọ morphin na-eji dị ka opioid analgesic na opioid antagonist/antidote. Ọ na-eme dị ka onye na-emegide μ-opioid receptor (MOR) na dị ka agonist nke κ-opioid receptor (KOR), na n'ihi ya, na-egbochi mmetụta nke ndị ọrụ siri ike na-arụ ọrụ dị ukwuu dị ka morphine ebe n'otu oge na-emepụta analgesia. . Dị ka agonist nke KOR, levallorphan nwere ike iwepụta mmeghachi omume uche siri ike na usoro zuru oke gụnyere ịhụ anya, dissociation, na mmetụta psychotomimetic ndị ọzọ, dysphoria, nchekasị, mgbagwoju anya, dizziness, disorientation, dealization, mmetụta nke ịṅụbiga mmanya ókè, na ihe jọgburu onwe ya, pụrụ iche, ma ọ bụ na-akpasu nrọ nrọ. . (Isi mmalite: https://en.wikipedia.org/wiki/Levallorphan). |
| CPD100575 | Turofexorate - isoropyl | Turofexorate isopropyl, nke a makwaara dị ka WAY-362450 na XL335, bụ nnukwu ike, nhọrọ, na onye na-arụ ọrụ agonist nke farnesoid X receptor (FXR) (EC (50) = 4 nM, Eff = 149%), nke na-eme ka ọnya imeju na-ebelata. na fibrosis na ụdị murine nke steatohepatitis na-abụghị mmanya |
| CPD100574 | GW4064 | GW4064是一种farnesoid X receptor (FXR)激动剂，CV1细胞系中EC50为65 nM。 |
| CPD1549 | Ọgwụgwọ nke Tropifexor | Tropifexor bụ akwụkwọ akụkọ na nnukwu ike agonist nke FXR nwere EC50 nke 0.2 nM. |
