Adavivint

Aha kemịkalụ:

N-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3 - methylbutanamide

Koodu Ọchịchọ:

CC(C)CC(NC1=CC(C2=CC3=C(NN=C3C(N4)=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C=C2)=CN= C1)=O

Koodu InChi:

InChi=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28( 37-36-24)29-34 -25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9-16H,8H2,1-2H3,( H,33,38)(H,34,35)(H,36,37)

Igodo InChi:

AQDWDWAYVBQMAM-UHFFFAOYSA-N

Okwu:

Adavivint, SM04690, SM-04690, SM 04690, 1467093-03-3

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

Ihe mgbochi obere mkpirisi Wnt nke nwere EC50 nke 3 nM in vitro; na-eme ka hMSC dị iche n'ime tozuru okè, chondrocytes na-arụ ọrụ ma na-ebelata ọkwa nrịbama catabolic cartilage; na-eme ka ọnụọgụ akụkọ ihe mere eme nke Osteoarthritis Research Society International (OARSI) dịkwuo mma na ndị na-ahụ maka biomarkers n'ụdị OA òké.

Ebumnuche: WNT