Flibanserin

Aha kemịkalụ:

1- (2- (4- (3- (trifluoromethyl) phenyl) piperazin-1-yl) ethyl) -1H-benzo [d] imidazole-2 (3H) - otu hydrochloride.

Koodu Ọchịchọ:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

Koodu InChi:

InChi=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

Igodo InChi:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Okwu:

Flibanserin, 167933-07-5

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

Flibanserin bụ agonist zuru oke nke onye na-anabata 5-HT1A (Ki = 1 nM) yana, yana mmekọrịta dị ala, dị ka onye na-emegide onye na-anabata 5-HT2A (Ki = 49 nM) na onye na-emegide ma ọ bụ agonist akụkụ na-adịghị ike nke D4. Ki = 4–24 nM). N'agbanyeghị nnukwu mmekọrịta dị n'etiti flibanserin maka onye na-anabata 5-HT1A, na maka ihe ndị a na-amaghị, flibanserin na-ejide 5-HT1A na 5-HT2A na vivo na pasent ndị yiri ya. Flibanserin nwekwara mmekọrịta dị ala maka onye na-anabata 5-HT2B (Ki = 89.3 nM) na onye na-anabata 5-HT2C (Ki = 88.3 nM), nke ọ na-eme dị ka onye na-emegide ya. Flibanserin na-arụ ọrụ nke ọma na ndị na-anabata 5-HT1A na prefrontal cortex, na-egosipụta nhọrọ mpaghara, wee chọpụta na ọ na-abawanye ọkwa dopamine na norepinephrine ma belata ọkwa serotonin na cortex prefrontal oke, omume ndị e kpebisiri ike na a ga-edozi ya site na ịgbalite 5-HT1A. onye nnabata.[12] Dị ka nke a, a kọwawo flibanserin dị ka onye na-egbochi norepinephrine-dopamine (NDDI). A kwadoro Flibanserin n'August 2015 maka ọgwụgwọ nke ndị inyom na-ebute ụzọ tupu ha enwee agụụ mmekọahụ hypoactive (HSDD).

Ebumnuche: 5HT