FGFR

nwamba # Aha ngwaahịa Nkọwa
CPD100464 Erdafitinib Erdafitinib, nke a makwaara dị ka JNJ-42756493, bụ onye nwere ike ma na-ahọrọ ọnụ ọnụ bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor nwere ike antineoplastic ọrụ. N'elu nchịkwa ọnụ, JNJ-42756493 na-ejikọta ma na-egbochi FGFR, nke nwere ike ịkpata nkwụsị nke ụzọ ntụgharị mgbaàmà metụtara FGFR ma si otú ahụ gbochie mmụba cell tumo na ọnwụ mkpụrụ ndụ tumo na FGFR-na-egosipụta oke mkpụrụ ndụ tumor. FGFR, nke edoziri n'ọtụtụ ụdị cell tumor, bụ tyrosine kinase nnabata nke dị mkpa maka mmụba cell tumor, ọdịiche na nlanarị.
CPD3618 TAS-120 TAS-120 bụ onye na-egbochi ọnụ nke bioavailable inhibitor nke fibroblast growth factor receptor (FGFR) nwere ọrụ antineoplastic nwere ike. FGFR inhibitor TAS-120 na-ahọrọ ma na-agbanweghi agbanwe na-ejikọta ma na-egbochi FGFR, nke nwere ike ịkpata nkwụsị nke ma ụzọ ntụgharị mgbaàmà nke FGFR na mmụba cell tumor, na ụbara ọnwụ cell na FGFR-na-egosipụta oke mkpụrụ ndụ tumor. FGFR bụ tyrosine kinase nnabata nke dị mkpa maka mmụba cell tumor, ọdịiche na nlanarị na okwu ya na-edozi n'ọtụtụ ụdị cell tumor.
CPDB1093 Derazantib; ARQ-087 Derazantinib, nke a makwaara dị ka ARQ-087, bụ onye na-emechi ọnụ nke ihe na-eme ka fibroblast growth factor receptor (FGFR) nwere ọrụ antineoplastic.
CPDB0942 BLU-554 BLU-554 bụ onye na-emechi ihe na-eme ka fibroblast na-anabata 4 (FGFR4) nwere ike ịgwọ ọrịa carcinoma hepatocellular na cholangiocarcinoma.
CPD0999 H3B-6527 H3B-6527 (H3 Biomedicine) bụ onye mmechi FGFR4 ahọpụtara nke ukwuu nwere ọrụ antitumour siri ike na ahịrị cell gbagoro agbagoro na ụmụ oke FGF19.
CPD0997 FGF401 FGF-401 bụ ihe mgbochi nke FGFR4 ewepụtara na patent WO2015059668A1, ihe atụ nke 83; nwere IC50 nke 1.9 nM.
CPDB0053 AZD4547 AZD 4547 bụ onye na-emechi nhọrọ nke fibroblast growth factor receptor (FGFR) tyrosine kinase nwere ụkpụrụ IC50 nke 0.2, 2.5, na 1.8 nM maka FGFR1, 2, na 3, n'otu n'otu.
CPD3610 BLU-9931 BLU9931 bụ onye nwere ike, nhọrọ na onye na-egbochi FGFR4 na-enweghị ike ịgbanwe ya na IC50 nke 3 nM, ihe dịka 297-, 184-, na 50-fold selectivity n'elu FGFR1/2/3, otu.
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