Ndị otu anyị na-ahụ maka ọgwụ na-ahụ maka mmepe preclinical, nyocha DMPK na ndebanye aha IND. Anyị guzobere ikpo okwu teknụzụ agbakwunyere na vitro & in vivo iji kwado nchọpụta na mmepe ọgwụ. Caerulum Pharma na-enye ọrụ na-agbanwe agbanwe na ahaziri iche maka ngwọta DMPK dị mma yana ọnụ ahịa iji kwalite nyocha gị n'ihu.
1.Study components
Obere ụmụ irighiri ihe, ngwaahịa eke, polypeptides.
2.dị ọrụ
Nnwale na-ejikọta protein na anụ ahụ / Plasma
Plasma ka ọbara ruru
Imeju microsomal metabolic kwụsie ike
Nkwụsi ike na ụgbọ ala na plasma
Nchọpụta metabolite
phenotyping mmeghachi omume CYP
Mgbochi CYP
3.Na-ewu
Mmebi nke imeju hepatocyte
Caco-2 Permeability
UGT mmeghachi omume phenotyping