Bardoxolone
Nkọwa ngwaahịa
Mkpado ngwaahịa
Nha ngwugwu | Nnweta | Ọnụ ego (USD) |
100mg | Dị na ngwaahịa | 300 |
500mg | Dị na ngwaahịa | 1000 |
1g | Dị na ngwaahịa | 1700 |
Nha ndị ọzọ | Nweta Quotes | Nweta Quotes |
Aha kemịkalụ:
(4aS,6aR,6bS,8aR,12aS,14aR,14bS) -11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-diox o-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic acid
Koodu Ọchịchọ:
CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CCC(C)(C[C@])2([C@]13[H) ])[H])C)C(O)=O)C)4C)5[H])C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
Koodu InChi:
InChi=1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22- 28 (5) 15-18 (17-32) 24 (34 )27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36) /t19-,21-,23-,28-,29+,30+,31-/m0/s1
Igodo InChi:
TXGZJQLMVSIZEI-UQMAOPSPSA-N
Okwu:
Bardoxolone, RTA 402, CCDO, RTA-402, RTA402, 218600-44-3
Solubility:Soluble na DMSO
Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).
Nkọwa:
Akụkụ akụrụ sitere na enwe a na-agwọ Bardoxolone methyl na-egosi mbelata okwu protein megalin n'agbanyeghị ụdị mRNA ahụ n'ofe otu. Nlebanya densitometry gosipụtara mbelata a na-ahụ anya na ngosipụta protein megalin, bụ nke gosipụtara na nchịkwa Bardoxolone methyl belatara nke ukwuu na ngosipụta protein megalin n'ime akụrụ enwe. Ọchịchị Bardoxolone methyl anaghị emetụta nkwupụta protein nke cubilin na akụrụ ma ọ bụ okwu mRNA nke cubilin na akụrụ. Mwepụ nke creatinine na enwe nke a na-enye Bardoxolone methyl dị iche na nke ahụ na ntọala na n'ime anụmanụ ndị a na-emeso ụgbọ na ụbọchị 28. Mgbe ụbọchị 28 gasịrị nke nchịkwa Bardoxolone methyl, urinary albumin-to-creatinine ratios (UACRs), kpebisiri ike site na mmamịrị 24-hour. mkpokọta, na-abawanye nke ukwuu ma e jiri ya tụnyere ndị nọ n'anụmanụ na-anata ụgbọ ala. N'ịmara, UACRs na-ebelata 53.3% n'ime anụmanụ ndị a na-agwọ ụgbọ ma mụbaa 27.9% na enwe-agwọ Bardoxolone methyl[3]. A na-enye ụmụ oke C57BL/6J ọnụ BARD n'oge nri HFD (HFD/BARD), naanị na-eri nri nwere oke abụba (HFD), ma ọ bụ nri nwere obere abụba (LFD) maka izu 21. E jiri ya tụnyere ụmụ oke LFD, ụmụ oke HFD nwere mmụba pụtara ìhè n'ọnụọgụ F4/80 ihe owuwu yiri okpueze (+95%; p<0.001), nke BARD gbochiri nke ọma (-50%; p<0.01). N'otu aka ahụ, ọnụọgụ F4/80 interstitial macrophages dị elu nke ukwuu na ụmụ oke HFD site na 98% (p.<0.001) atụnyere ụmụ oke LFD yana site na 32% (p<0.01) atụnyere ụmụ oke HFD/BARD[4].
Ebumnuche: Nrf-2