FLT3

nwamba #	Aha ngwaahịa	Nkọwa
CPDB0099	Quizartinib; AC-010220; AC-220	Quizartinib bụ onye na-egbochi FMS metụtara tyrosine kinase 3 (FLT3; Kd = 1.6 nM) ma gosipụta oke nhọrọ maka FLT3 mgbe a nwalere ya na panel nke 227 ọzọ kinases. Ọ na-egbochi mmụba nke eriri mkpụrụ ndụ leukemia mmadụ MV4-11, nke na-ebunye ngbanwe nke homozygous FLT3-ITD, yana uru IC50 nke 0.56 nM.1 Na 1 mg / kg / ụbọchị, quizartinib egosila ịgbatị ndụ n'ime òké. ụdị nke FLT3-ITD nnukwu ọrịa leukemia myeloid na ikpochapụ etuto dị na ụdị xenograft òké FLT3 dabere na 10 mg/kg.