Ozanimod

Ainm Ceimigeach:

(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-il)-1,2,4-oxadiazol-5-yl)-2 -isopropoxybenzonitrile

Còd SMILES:

N#CC1=CC(C2=NC(C3=CC=CC4=C3CC[C@H]4NCCO)=NO2)=CC=C1OC(C)C

Còd InChi:

InChI=1S/C23H24N4O3/c1-14(2)29-21-9-6-15(12-16(21)13-24)23-26-22(27-30-23)19-5-3- 4 -18-17(19)7-8-20(18)25-10-11-28/h3-6,9,12,14,20,25,28H,7-8,10-11H2,1-2H3 /t20-/m0/s1

iuchair InChi:

XRVDGNKRPOAQTN-FQEVSTJZSA-N

Facal-luirg:

Ozanimod, RPC-1063, RPC1063, RPC 1063, 1306760-87-1

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).

Tuairisgeul:

Tha Ozanimod na mhodulator roghnach, ri fhaighinn gu beòil de na gabhadairean sphingosine-1-phosphate (S1P) S1P1 agus SIP5. Bidh e a 'toirt a-steach taobh a-staigh S1P1, a' lùghdachadh lymphocytes B agus CCR7 (+) T, agus a 'lùghdachadh crìochan sèid agus galair ann an trì modalan galair fèin-fhìn.1 Tha Ozanimod ann an deuchainnean clionaigeach airson sglerosis iomadach agus colitis ulcerative ath-chuairteachadh.

Targaid: S1P