BLU-554

Ainm Ceimigeach:

N-((3S,4S)-3-(6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide

Còd SMILES:

C=CC(N[C@@H]1[C@H](NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2) COCC1)=o

Còd InChi:

InChI=1S/C24H24Cl2N4O4/c1-4-20(31)28-16-7-8-34-12-17(16)30-24-27-11-14-9-13(5-6-15( 14) 29-24) 21-22(2 5) 18(32-2)10-19(33-3)23(21)26/h4-6,9-11,16-17H,1,7-8,12H2,2-3H3,(H,28 ,31)(H,27,29,30)/t16-,17+/m0/s1

iuchair InChi:

MGZKYOAQVGSSGC-DLBZAZTESA-N

Facal-luirg:

BLU-554, BLU554, BLU-554, 1707289-21-1

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).

Tuairisgeul:

Tha BLU-554 na neach-dìon fàis fibroblast gabhadair 4 (FGFR4) a dh’ fhaodadh a bhith ann airson làimhseachadh carcinoma hepatocellular agus cholangiocarcinoma.

Targaid: FGFR