Ciforadenant

Ainm Ceimigeach:

(S)-7-(5-methylfuran-2-yl)-3-(6-((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2 ,3] triazolo [4,5-d] pyrimidin-5-amine

Còd SMILES:

NC1=NC2=C(N=NN2CC3=NC(CO[C@H]4CCOC4)=CC=C3)C(C5=CC=C(O5)C)=N1

Còd InChi:

InChI=1S/C20H21N7O3/c1-12-5-6-16(30-12)17-18-19(24-20(21)23-17)27(26-25-18)9-13-3- 2-4-14(22-13)10-29-15-7-8-28-11-15/h2-6,15H,7-11H2,1H3,(H2,21,23,24)/t15- /m0/s1

iuchair InChi:

KURQKNMKCGYWRJ-HNNXBMFYSA-N

Facal-luirg:

Ciforadenant, CPI-444, V81444, CPI444, CPI 444

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)

Tuairisgeul:

Tha CPI-444 na antagonist roghnach làidir, ri fhaighinn gu beòil, den receptor adenosine A2A a chaidh gabhail ris gu math ann an sgrùdaidhean Ph 1 / 1b ann an comharran neo-oncology.

Targaid: Adenosine A2A