MSC2530818
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 100mg | O wa | 400 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
[(2S) -2- (4-Chlorophenyl) pyrrolidin-1-yl] (3-methyl-1H-pyrazolo [3,4-b] pyridin-5-yl) methanone
KỌỌDỌ SMILES:
O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
Koodu InChi:
InChi=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4- 6-14 (19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1
Bọtini InChi:
ODRITQGYYWHQGM-INIZCTEOSA-N
Koko-ọrọ:
MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).
Apejuwe:
MSC2530818 jẹ Agbara, Yiyan, ati Orally Bioavailable CDK8 Inhibitor pẹlu CDK8 IC50 = 2.6 nM; Asọtẹlẹ PK eniyan: Cl ~ 0.14 L / H / Kg; t1/2 ~ 2.4h; F > 75%. MSC2530818 ṣe afihan yiyan kinase to dara julọ, biokemika ati agbara cellular, iduroṣinṣin microsomal, ati pe o wa bioavailable ni ẹnu. MSC2530818 ṣe afihan agbara ti o yẹ ati yiyan lati ni ilọsiwaju si iṣaju iṣaju ni ipa vivo ati awọn ikẹkọ ailewu.
afojusun: CDK
