Verucerfont

Orukọ Kemikali:

(S) -3- (4-methoxy-2-methylphenyl) -2,5-dimethyl-N- (1- (3-methyl-1,2,4-oxadiazol-5-yl) propyl) pyrazolo [1, 5-a] pyrimidin-7-amin

KỌỌDỌ SMILES:

CC[C@H](NC1=CC(C)=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN12)C4=NC(C)=NO4

Koodu InChi:

InChi=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14) (4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/ s1

Bọtini InChi:

VKHVAUKFLBBZFJ-SFHVURJKSA-N

Koko-ọrọ:

Verucerfont, GSK561679, GSK 561679, GSK-561679, NBI77860, NBI 77860, NBI-77860, 885220-61-1

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

"Verucerfont, ti a tun mọ ni GSK561679 ati NBI77860, jẹ antagonist CRF-1. Verucerfont ṣe idiwọ olugba CRH-1, ati pe o dinku igbasilẹ ACTH lẹhin aapọn onibajẹ. O wa labẹ iwadi bi itọju ti o pọju fun ọti-lile, bi aapọn onibaje nigbagbogbo jẹ nigbagbogbo. ifosiwewe kan ninu idagbasoke mejeeji ti ọti-lile ati ifasẹyin ni gbigbapada awọn ọti-lile O ti ṣe afihan awọn abajade ileri ninu awọn iwadii ẹranko ṣugbọn ko ti ni idanwo ninu eniyan."

Àkọlé: CRF-1