MC180295
Mahsulot detali
Mahsulot teglari
| Paket hajmi | Mavjudligi | Narxi (AQSh dollari) |
Kimyoviy nomi:
Rel-(4-amino-2-(((2S)-bisiklo[2.2.1]geptan-2-il)amino)tiazol-5-il)(2-nitrofenil)metanon
SMILE kodi:
O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O
InChi kodi:
InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8- 9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1
InChi kaliti:
JRNXAQINDCOHGS-CBINBANVSA-N
Kalit so'z:
Eruvchanligi:
Saqlash:
Tavsif:
MC180295 juda selektiv CDK9 inhibitori (IC50 = 5 nM). (MC180295 in vitro saratonga qarshi keng faollikka ega va in vivo saraton modellarida samarali. Bundan tashqari, CDK9 inhibisyoni in vivo jonli ravishda a-PD-1 immun nazorat nuqtasi inhibitori uchun sezgir bo'lib, uni saraton epigenetik terapiyasi uchun ajoyib nishonga aylantiradi.
Maqsad: CDK9
