| CAT # | Mahsulot nomi | Tavsif |
| CPDB0099 | Quizartinib; AC-010220; AC-220 | Quizartinib FMS bilan bog'liq tirozin kinaz 3 (FLT3; Kd = 1,6 nM) inhibitori bo'lib, 227 qo'shimcha kinazlar paneliga qarshi sinovdan o'tkazilganda FLT3 uchun yuqori selektivlikni namoyish etadi. U gomozigotli FLT3-ITD mutatsiyasiga ega bo'lgan, IC50 qiymati 0,56 nM bo'lgan MV4-11 inson leykemiya hujayralarining ko'payishini inhibe qiladi. FLT3-ITD o'tkir miyeloid leykemiya modeli va o'smalarni yo'q qilish 10 mg/kg da FLT3 ga bog'liq sichqoncha ksenograft modeli. |
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