SB-204990

Ngaran Kimia:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

Kode SMILES:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Kodeu InChi:

InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,1) 1-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

Konci InChi:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

kecap konci:

SB-204990, SB 204990, SB204990

Kalarutan: 

Panyimpenan: 

Katerangan:

SB-204990 nyaéta prodrug tina ATP citrate-lyase inhibitor potent SB-201076. SB-204990, nalika dikaluarkeun sacara lisan ka beurit, diserep kana sirkulasi sistemik, konsentrasi pharmacologically relevan SB-201076 pulih dina ati. SB-204990 (25 mg/kg per poé) ogé nurunkeun kadar kolesterol plasma (nepi ka 23%) jeung tingkat trigliserida (nepi ka 38%) dina anjing, preferentially nurunna low-density lipoprotein dibandingkeun jeung high-density lipoprotein kolesterol. tingkatan. SB-204990 mangrupikeun énzim anu penting dina ngatur suplai substrat pikeun sintésis lipid de novo sareng target énzim poténsial pikeun intervensi hypolipidaemic.

Sasaran: