| Ucing # | Ngaran produk | Katerangan |
| CPD3611 | SB-204990 | SB-204990 nyaéta prodrug tina ATP citrate-lyase inhibitor potent SB-201076. SB-204990, nalika dikaluarkeun sacara lisan ka beurit, diserep kana sirkulasi sistemik, konsentrasi pharmacologically relevan SB-201076 pulih dina ati. SB-204990 (25 mg/kg per poé) ogé nurunkeun kadar kolesterol plasma (nepi ka 23%) jeung tingkat trigliserida (nepi ka 38%) dina anjing, preferentially nurunna low-density lipoprotein dibandingkeun jeung high-density lipoprotein kolesterol. tingkatan. SB-204990 mangrupikeun énzim anu penting dina ngatur suplai substrat pikeun sintésis lipid de novo sareng target énzim poténsial pikeun intervensi hypolipidaemic. |
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