PRT-060318; PRT318; P142–76
Rincian produk
Tag produk
| Ukuran Pek | Kasadiaan | Harga (USD) |
| 500 mg | Aya sasayogian | 900 |
| 1g | Aya sasayogian | 1350 |
| Langkung Ukuran | Meunang Tanda kutip | Meunang Tanda kutip |
Ngaran Kimia:
2-(((1R, 2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pirimidin-5-carboxamide
Kode SMILES:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
Kodeu InChi:
InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1
Konci InChi:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
kecap konci:
PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Kalarutan:Leyur dina DMSO
Panyimpenan:0 - 4°C kanggo jangka pondok (poé ka minggu), atanapi -20°C kanggo jangka panjang (bulan)
Katerangan:
PRT060318 mangrupakeun inhibitor potent tur selektif tina limpa tirosin kinase (Syk; IC50 = 4 nM). Éta selektif, inhibiting 92% tina aktivitas Syk, bari kinase séjén nahan aktivitas> 70%, dina konsentrasi 50 nM dina panel of 270 kinase. PRT060318 nyegah aggregation convulxin-ngainduksi tina plasma-euyeub trombosit manusa (IC50 = 2.5 μM) in vitro sarta nyegah trombosis dina modél mouse transgenik thrombocytopenia heparin-ngainduksi. Éta nyababkeun apoptosis sél limfositik kronis (CLL) B sareng ngahambat sékrési kémokin CCL3, CCL4, sareng CXCL13.3 PRT060318 ogé ngahambat kemotaksis sél CLL B sareng pseudoemperipolesis.
Sasaran: Sy
