Batefenterol
Rincian produk
Tag produk
| Ukuran Pek | Kasadiaan | Harga (USD) |
| 50 mg | Aya sasayogian | 200 |
| 250 mg | Aya sasayogian | 600 |
| 500 mg | Aya sasayogian | 900 |
| 1g | Aya sasayogian | 1400 |
| Langkung Ukuran | Meunang Tanda kutip | Meunang Tanda kutip |
Ngaran Kimia:
"(R) -1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) etil)amino) métil) -5-metoxyphenyl) amino)-3-oxopropyl) piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"
Kode SMILES:
O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6
Kodeu InChi:
InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30( 29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(16-19-46)53-40(51)44-32-10- 6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2, 1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1
Konci InChi:
URWYQGVSPQJGGB-DHUJRADRSA-N
kecap konci:
Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6
Kalarutan:Leyur dina DMSO
Panyimpenan:0 - 4°C kanggo jangka pondok (poé ka minggu), atanapi -20°C kanggo jangka panjang (bulan)
Katerangan:
Batefenterol mangrupikeun antagonis muscarinic sareng agonis reséptor β2-adrenergic (β2-AR) (Kis = 1.4, 1.3, sareng 3.7 nM, pikeun hM2, hM3, sareng hβ2-AR, masing-masing dina assay beungkeutan radioligand). Batefenterol némbongkeun potent hβ2-AR aktivitas agonist (EC50 = 0.29 nM) kalawan 440- na 320-melu selektivitas fungsi leuwih hβ1- na hβ3-ARs, respectively.1 Batefenterol induces rélaxasi otot lemes (EC50 = 11 nM) dina tracheal marmot terasing jaringan sareng ngahambat réspon bronkokonstriktor dina uji bronkoproteksi guinea pig (ED50 = 6.4 µg/mL). Formulasi anu ngandung batefenterol aya dina uji klinis pikeun ngubaran kasakit paru obstructive kronis (COPD).
Sasaran: β2-adrenoceptor
