THZ531
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 100mg | Mudura | 500 |
| 500mg | Mudura | 800 |
| 1g | Mudura | 1200 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (dimethylamino) asi-2-enamide
SMILES Kodhi:
"O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C "
InChi Code:
InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4, 6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/ t22-/m1/s1
InChi Key:
RUBYHLPRZRMTJO-MOVYNIQHSA-N
Keyword:
THZ-531, THZ 531, THZ531, 1702809-17-3
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).
Tsanangudzo:
THZ531 ndeye covalent CDK12 uye CDK13 covalent inhibitor. Cyclin-inotsamira kinases 12 uye 13 (CDK12 uye CDK13) inotamba mabasa akakosha mukutonga kwekunyorwa kwemajini. THZ531 isingachinjiki inonongedza cysteine iri kunze kwekinase domain. THZ531 inokonzera kurasikirwa kwejini kutaura nekurasikirwa kwakafanana kwekurebesa uye hyperphosphorylated RNA polymerase II. THZ531 inoderedza zvakanyanya kutaura kweDNA kukuvadza mhinduro majini uye kiyi yepamusoro-enhancer-yakabatana transcription factor genes. THZ531 yakakonzera kufa kwesero apoptotic. Mamorekuru madiki anokwanisa kunanga zvakananga kuCDK12 uye CDK13 anogona kubatsira kuona cancer subtypes inonyanya kutsamira pane yavo kinase zviitiko.
Chinangwa: CDK
