PQR530
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 100mg | Mudura | 500 |
| 500mg | Mudura | 800 |
| 1g | Mudura | 1200 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
(S) -4-(difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine
SMILES Kodhi:
NC1=NC=C(C2=NC(N3[C@H](C)COCC3)=NC(N4CCOCC4)=N2)C(C(F)F)=C1
InChi Code:
InChI=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(19)20) 23-17(25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/t11-/m0 /s1
InChi Key:
SYKBZXMKAPICSO-NSHDSACASA-N
Keyword:
PQR530, PQR-530, PQR 530, 1927857-61-1
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).
Tsanangudzo:
PQR530 ine simba kwazvo mbiri mbiri pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) uye ribosomal protein S6 (pS6, pSer235/236) phosphorylation ine IC50 kukosha kwe0.07 µM. PQR530 yakaratidza kusarudzika kwakanakisa pamusoro penzvimbo yakafara yekinases, pamwe nekusarudzika kwakanakisa kunopesana neasina hukama mareceptor enzymes uye ion nzira. Uyezve, PQR530 yakaratidza potency mupaneru ye44 cancer cell lines (NTRC Oncolines TM) kudzivirira cancer cell kukura (kureva kukosha kweGI50 ye426 nM). Kushandiswa kwemuromo kwePQR530 kumakonzo kwakaguma nedose-proportional PK uye yakaratidza yakanaka yemuromo bioavailability uye yakanakisa uropi kupinda.
Chinangwa: PI3K/mTOR
