BLU-667

Chemical Name:

(1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl)phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

SMILES Kodhi:

CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

InChi Code:

InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5 -7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13-16,19,21H,9-12H2,1-4H3,(H,32, 38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

InChi Key:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

Keyword:

BLU-667; BLU 667; BLU667

Solubility:DMSO

Kuchengeta: 

Tsanangudzo:

BLU-667 ine simba uye inosarudza inhibitor yeRET mutations, fusions, uye kufanotaura kusagadzika mutants. RET fusions madhiraivha akakosha ecancer akawanda, anosanganisira kenza yemapapu neyethyroid, uye tsvagiridzo yedu inoratidza kuti RET inoitawo basa rakakosha mune mamwe makoron uye mazamu. Nekunangisa panguva imwe chete kumutyairi wekutanga uye akafanotaura anopokana nekuchinja izvo zvinoita kuti masero egomarara asanzwe kurapwa nemishonga yakabvumidzwa parizvino,

Chinangwa: RET