MSC2530818

Chemical Name:

[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

SMILES Kodhi:

O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3

InChi Code:

InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0/s1

InChi Key:

ODRITQGYYWHQGM-INIZCTEOSA-N

Keyword:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).

Tsanangudzo:

MSC2530818 ine Simba, Inosarudza, uye Nemuromo Bioavailable CDK8 Inhibitor ine CDK8 IC50 = 2.6 nM; Kufanotaura kwevanhu PK: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. MSC2530818 inoratidza yakanakisa kinase selectivity, biochemical uye cellular potency, microsomal kugadzikana, uye inowanikwa nemuromo bioavailable. MSC2530818 inoratidza yakakodzera potency uye kusarudza kufambira mberi mune preclinical in vivo efficacy uye kuchengetedza zvidzidzo.

Chinangwa: CDK