Nazartinib; EGF816; NVS-816
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 25mg | Mudura | 290 |
| 50mg | Mudura | 450 |
| 100mg | Mudura | 630 |
| 1g | Mudura | 1600 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)asi-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)- 2-methylisonicotinamide
SMILES Kodhi:
O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)= C4
InChi Code:
InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33( 26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5, 8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1
InChi Key:
IOMMMLWIABWRKL-WUTDNEBXSA-N
Keyword:
Nazartinib ,EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)
Tsanangudzo:
Nazartinib, inozivikanwawo seEGF816 uye NVS-816, inowanikwa nemuromo, isingadzokerike, yechitatu-chizvarwa, inosarudzika epidermal growth factor receptor (EGFR) inhibitor, ine inogona kuita antineoplastic. EGF816 yakabatana inosunga uye inhibits basa remutant mafomu eEGFR, kusanganisira iyo T790M EGFR mutant, nekudaro kudzivirira kusaina kweEGFR-mediated. Izvi zvinogona kukonzera kufa kwesero uye kutadzisa bundu kukura muEGFR-overexpressing tumor cell. EGF816 inonyanya kuvharidzira mafomu akachinja eEGFR anosanganisira T790M, akawanikwa kechipiri ekuramba shanduko, uye anogona kuve nekurapa kwakanaka mumamota ane T790M-mediated resistance kana ichienzaniswa nemamwe EGFR tyrosine kinase inhibitors.
Chinangwa: EGFR
