BI-847325
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 100mg | Mudura | 400 |
| 500mg | Mudura | 950 |
| 1g | Mudura | 1400 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
SMILES Kodhi:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4
InChi Code:
InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-2 2)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2,1-3H3,(H,30 ,34)(H,32,35)/b28-27-
InChi Key:
FLBNLJLONKAPLR-DQSJHHFOSA-N
Keyword:
BI-847325, BI847325, BI 847325, 1207293-36-4
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)
Tsanangudzo:
BI-847325 is selective dual MEK/Aurora kinase inhibitor ine IC50 values dze 3, 25, 15, 25, uye 4 nM ye X. laevis Aurora B, munhu Aurora A uye Aurora C, uye MEK1 yevanhu uye MEK2, zvichiteerana. Inogona kumisa kukura uye kurarama kweaviri-asina kurapa uye anodzivirira zvinodhaka melanoma cell mitsara, ichideredza kutaura kweMEK neMcl-1 uku ichiwedzera kutaura kwepro-apoptotic protein Bim. Pa 70 mg/kg, BI-847325 induces apoptosis mukurapa-naive uye zvinodhaka-resistant xenografted melanoma in vivo.
Chinangwa: MEK/Aurora
