BS-181
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
Chemical Name:
N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine hydrochloride
SMILES Kodhi:
CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl
InChi Code:
InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19)28 )24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2, 1-2H3,(H,24,27);1H
InChi Key:
NVIJWMOQODWNFN-UHFFFAOYSA-N
Keyword:
Solubility:
Kuchengeta:
Tsanangudzo:
BS-181 inonyatso kusarudza CDK inhibitor yeCDK7 ine IC(50) ye21 nmol/L. Kuongororwa kwemamwe maCDK pamwe nemamwe makumi matanhatu nemapfumbamwe kinase kwakaratidza kuti BS-181 yakangovharira CDK2 pamitsetse yakaderera pane 1 micromol/L, neCDK2 ichivharirwa makumi matatu neshanu zvishoma zvine simba (IC(50) 880 nmol/L) pane CDK7. Mumasero eMCF-7, BS-181 yakadzivisa phosphorylation yeCDK7 substrates, yakasimudzira kusungwa kwesero cycle uye apoptosis kudzivisa kukura kwekenza cell mitsara, uye yakaratidza antitumor madhara mu vivo.
Chinangwa: CDK7
