LDC000067

LDC000067
  • Zita:LDC000067
  • Catalog Nhamba:1073485-20-7
  • Nhamba yeCAS:1073485-20-7
  • Molecular Weight:370.11
  • Chemical Formula:C18 H18 N4 O3 S
  • Kutsvakurudza kwesayenzi chete, kwete kuvarwere.

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    Chemical Name:

    3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

    SMILES Kodhi:

    O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

    InChi Code:

    InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6 -4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

    InChi Key:

    GGQCIOOSELPMBB-UHFFFAOYSA-N

    Keyword:

    LDC000067; LDC-000067; LDC 000067

    Solubility: 

    Kuchengeta: 

    Tsanangudzo:

    LDC000067 ine simba uye inosarudza CDK9 inhibitor. LDC000067 inhibited in vitro transcription nenzira yeATP-yemakwikwi uye inotsamira muyero. Gene expression profiling yemasero akabatwa neLDC000067 yakaratidza kuderedzwa kwakasarudzika kwemamRNAs enguva pfupi, kusanganisira akakosha ekudzora kupararira uye apoptosis. Ongororo ye de novo RNA synthesis yakakurudzira basa rakasiyana-siyana rakanaka reCDK9. Payero yemamorekuru nemaserura, LDC000067 yakadzokorodza maitiro eCDK9 inhibition senge kukwidziridzwa kumbomira kweRNA polymerase II pamajini uye, zvakanyanya kukosha, kuiswa kweapoptosis mumasero egomarara. LDC000067 inhibits P-TEFb-inotsamira mu vitro transcription. Inoita kuti apoptosis in vitro uye mu vivo musanganiswa neBI 894999.

    Chinangwa: CDK9


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